Manufacturer: Maxtreme
Category: Anti Estrogens
Substance: Tamoxifen citrate (Nolvadex)
Package: 20mg (100 pills)



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Maxi-Fen-20 is an antitumor drug that has anti-estrogenic effects. It is able to competitively bind to estrogen receptors in target organs, and also prevents them from interacting with the endogenous ligand – 17-beta – estradiol. This causes inhibition of tumor development, which is stimulated by estrogen. Tamoxifen does not possess androgenic activity.


Maxi-Fen-20 is a non-steroid substance and has a pronounced anti-estrogen effect. Due to its ability to prevent the binding of estrogens to target organs (in their specific areas), it slows the growth of tumors that are stimulated with estrogens. The active ingredient is tamoxifentirate. One tablet contains tamoxifen citrate – 15.3 mg (equivalent to 10 mg of tamoxifen.

Auxiliary agents: sagidrofosfat, corn starch, povidone, talc, magnesium stearate, lactose. The release form – tablets of 10 mg; 20 mg; 40 mg, in blisters of 10 tablets, in a package – 30. Tablets are round, flat, white in color, do not have a shell, on the one hand notch. Dispensed by prescription, country of origin – India. In the pharmacotherapeutic group, they are classified as antineoplastic, antiestrogenic, and immunomodulating agents.

Indications for use:

  • postmenopausal breast cancer;
  • metastasized cancer in men;
  • endometrial cancer (inner layer of the uterus);
  • anovulatory infertility.

Action Maxi-Fen-20

It is quickly and efficiently absorbed after entering the gastrointestinal tract. The maximum concentration in the blood reaches after 4-7 hours, the equilibrium concentration reaches after one month of therapy. Metabolism in the liver occurs due to the processes of demethylation and hydroxylation, after which the formation of a number of metabolites, which have the same pharmacological profile with the original substance.

Tamoxifen is excreted in the bile, excretion in urine occurs in small quantities. The elimination process has an initial phase (7-14 hours) and a terminal phase (7 days). 14 days is the half-life of N-desmethyltamoxifen. Plasma tamoxifen concentration of more than 70 µg / l provides a clinical effect. The effect of the drug does not depend on food intake.

How to take Maxi-Fen-20

Instructions for use Tamoxifen, as well as the dose are set individually. In breast cancer, the daily dose is 20 mg, while generalizing the process, the dose is 30-40 mg per day. The maximum daily dose is 40 mg. The visible effect of treatment occurs after 4 to 10 weeks, if metastasis to the bone tissue is present, the effect may be observed at a later date. Tablets must be taken without chewing, drinking plenty of water. Drug therapy is long.

Tamoxifen can be combined with other chemotherapy drugs, as well as with radiation therapy. It is necessary to take the drug with caution in patients with diseases of the kidneys, liver, diabetes, with violations in the field of ophthalmology. Before starting treatment, it is necessary to carry out gynecological and therapeutic examinations for six months, and in the presence of anovulatory bleeding, abnormal discharge, pain, find out the reasons for their appearance.

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